"American Gothic" is a painting by Grant Wood in the collection of the Art Institute of Chicago. Wood's inspiration came from what is now known as the American Gothic House, and his decision to paint the house along with "the kind of people I fancied should live in that house." Painted in 1930, it depicts a farmer standing beside a woman that has been interpreted to be either his wife or his daughter. The figures were modeled by Wood's sister, Nan Wood Graham, and Wood and Graham's dentist, Dr. Byron McKeeby. The woman is dressed in a colonial print apron evoking 19th-century Americana, and the man is holding a pitchfork. The plants on the porch of the house are mother-in-law's tongue and beefsteak begonia, which are the same plants as in Wood's 1929 portrait of his mother, Woman with Plants.

It is one of the most familiar images in 20th-century American art, and has been widely parodied in American popular culture.